Publications

Publications

Publications

Find journal publications related to Botanix focus on skin disease.

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

Bíró T, Tóth BI, Haskó G, Paus R, Pacher P

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid mediators endocannabinoids present in virtually all tissues, their G-protein-coupled cannabinoid receptors, biosynthetic pathways and metabolizing enzymes) has been implicated in multiple regulatory functions both in health and disease. Recent studies have intriguingly suggested the existence of a functional ECS in the skin and implicated it in various biological processes (e.g. proliferation, growth, differentiation, apoptosis and cytokine, mediator or hormone production of various cell types of the skin and appendages, such as the hair follicle and sebaceous gland). It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. The disruption of this delicate balance might facilitate the development of multiple pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, systemic sclerosis and cancer).

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

Attila Oláh, Balázs I. Tóth, István Borbíró, Koji Sugawara, Attila G. Szöllõsi,Gabriella Czifra, Balázs Pál, Lídia Ambrus, Jennifer Kloepper,Emanuela Camera, Matteo Ludovici, Mauro Picardo, Thomas Voets,Christos C. Zouboulis, Ralf Paus, and Tamás Bíró

The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary focus of endocannabinoid biology has been on neurological and psychiatric effects, recent work has revealed several important interactions between the endocannabinoid system and cancer. The antiproliferative and apoptotic effects produced by some of these pharmacological probes reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer.

Epigenetic control of skin differentiation genes by phytocannabinoids

Mariangela Pucci, Cinzia Rapino, Andrea Di Francesco, Enrico Dainese, Claudio D'Addario and Mauro Maccarrone

Endocannabinoid signalling has been shown to have a role in the control of epidermal physiology, whereby anandamide is able to regulate the expression of skin differentiation genes through DNA methylation. Here, we investigated the possible epigenetic regulation of these genes by several phytocannabinoids, plant-derived cannabinoids that have the potential to be novel therapeutics for various human diseases

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